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Pfizer Slashed Its Original Covid-19 Vaccine Rollout Target After Supply Chain Obstacles

Pfizer Slashed Its Original Covid-19 Vaccine Rollout Target After Supply Chain Obstacles

December 4, 2020
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Pfizer Slashed Its Original Covid-19 Vaccine Rollout Target After Supply Chain Obstacles

December 4, 2020
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Pfizer Slashed Its Original Covid-19 Vaccine Rollout Target After Supply Chain Obstacles
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When Pfizer Inc. said last month it expects to ship half the Covid-19 vaccines it had originally planned for this year, the decision highlighted the challenges drug makers face in rapidly building supply chains to meet the high demand.

“Scaling up the raw material supply chain took longer than expected,” a company spokeswoman said. “And it’s important to highlight that the outcome of the clinical trial was somewhat later than the initial projection.”

Pfizer still expects to roll out more than a billion doses in 2021 as originally planned.

Pfizer and Germany-based partner BioNTech SE had hoped to roll out 100 million vaccines world-wide by the end of this year, a plan that has now been reduced to 50 million. The UK on Wednesday granted emergency-use authorization for the vaccine, becoming the first Western country to start administering doses.

The two-shot vaccine also is being reviewed by the Food and Drug Administration in the US, where a similar authorization could come later this month and a rollout before the end of the year. The US regulator also is considering a vaccine developed by Cambridge, Mass.-based Moderna Inc. that could begin shipping before Christmas.

The doses are among an array of vaccines that have been developed this year as the coronavirus pandemic has raged across much of the world. Authorities estimate nearly 1.5 million people world-wide have died from the virus, including 273,836 in the U.S. as of Dec. 2.

Pfizer had its 100-million dose goal in place until mid-November, when it became clear the supply-chain hurdles were too great for the end-of-the-year timeline.

“We were late,” said a person directly involved in the development of the Pfizer vaccine. “Some early batches of the raw materials failed to meet the standards. We fixed it, but ran out of time to meet this year’s projected shipments.”

Pfizer sources its raw materials from providers in the US and Europe. Scaling up production of these components proved challenging last month as the company awaited the results of its trials, which came in to be 95% effective and well-tolerated in a 44,000-subject trial.

Pfizer wouldn’t say where shortfalls over ingredients arose as it ramped up production. Vaccines typically contain materials from suppliers that can include antivirus agents, antiseptic liquids, sterile water and elements of the DNA of the virus itself that won’t cause serious symptoms but trigger the immune system to make antibodies.

In a typical vaccination campaign, pharmaceutical companies would wait until their product is approved before buying raw materials, establishing manufacturing lines and setting up supply chains to ship a vaccine. Pfizer has never manufactured a vaccine with technology that uses mRNA, the molecular couriers that carry genetic instructions to cells in the human body, so it has had to scale up production capacity even as research was still under way.

“For this one, everything happened simultaneously,” the person familiar with the Pfizer development said. “We started setting up the supply chain in March, while the vaccine was still being developed. That’s totally unprecedented.”

Pfizer and BioNtech are now on track to roll out 1.3 billion vaccines in 2021 and the 50 million dose shortfall this year will be covered as production ramps up.

The company is setting up what it has described as its biggest ever vaccination campaign through two final assembly and distribution centers in Kalamazoo, Mich., and Puurs, Belgium, which will handle the European supply.

The UK authorization marks a milestone in the effort to develop a promising new vaccine technology into a widely available shot in record time.

The UK ordered 40 million Pfizer doses, enough to vaccinate 20 million people. The government said in November that it could get up to 10 million doses this year, but the expectation now is that four to five million vaccines will be shipped.

UK Health Secretary Matt Hancock said the shots will be rolled out as quickly as they can be made at Pfizer’s Belgium plant. Some 800,000 are due in the coming days and “several millions” throughout December, he said.

The US government has placed an initial order for 100 million doses of the Pfizer vaccine, with the option to purchase 500 million additional doses.

The EU ordered 200 million doses with an option for another 100 million. Japan ordered 120 million doses, and countries in South America and in the Asia-Pacific region also have placed significant orders

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