At least one person has been killed and 15 injured in a missile strike on a medical clinic in Dnipro, in Ukraine’s east.
The regional governor, Serhiy Lysak, said two boys aged three and six years old are among the wounded.
Ukrainian President, Volodymyr Zelensky, confirmed the attack and said authorities were working to rescue others from the hospital.
Earlier, Mr Lysak said the city came under attack on Thursday night.
“It was a very difficult night. It was loud – the enemy launched a mass attack on the region with missiles and drones,” he said. “Dnipro has suffered.”
Mr Zelensky posted a video of the damaged clinic building that showed firefighters at the scene and smoke billowing from the building.
“Russian terrorists once again confirm their status of fighters against everything humane and honest,” he said.
Ukrainian authorities said they shot down 17 missiles and 31 drones launched from Russia overnight.
Several drones and missiles hit targets in Dnipro and the eastern city of Kharkiv, including an oil depot.
Ukraine’s capital, Kyiv, was also targeted and officials said fragments of intercepted drones fell on the roof of a shopping centre, while a house and several cars were damaged.
Russia has intensified its attacks on Ukraine in recent weeks, targeting its infrastructure facilities ahead of an expected Ukrainian counter-offensive.
Ukraine reportedly struck two regions in Russia’s south with a rocket and a drone on Thursday, but Russia said the missile was shot down by its air defence systems.
A blast damaged a residential and office building in the southern Russian city of Krasnodar, although it is unclear what caused it. Russian media have said it was a drone attack.